Radiometric correction procedure study

A comparison of MSS radiometric processing techniques identified as a preferred radiometric processing technique a procedure which equalizes the mean and standard deviation of detector-specific histograms of uncalibrated scene data. Evaluation of MSS calibration data demonstrated that the relationship between detector responses is essentially linear over the range of intensities typically observed in MSS data, and that the calibration wedge data possess a high degree of temporal stability. An analysis of the preferred radiometric processing technique showed that it could be incorporated into the MDP-MSS system without a major redesign of the system, and with minimal impact on system throughput

Thematic mapper design parameter investigation

This study simulated the multispectral data sets to be expected from three different Thematic Mapper configurations, and the ground processing of these data sets by three different resampling techniques. The simulated data sets were then evaluated by processing them for multispectral classification, and the Thematic Mapper configuration, and resampling technique which provided the best classification accuracy were identified

The Effect of the TyG Index on Liver Steatosis, Immune Activation, Oxidative Stress, Liver Fibrosis Pathways and Liver Fibrosis in the Miami Adult Studies on HIV (MASH) Cohort

The purpose of this study was to establish the Triglyceride-Glucose (TyG) Index Ln (fasting TG x fasting glucose/2) as a predictor of liver steatosis in People Living with HIV (PLWH) and determine the effect of increased TyG Index on biomarkers of immune activation, inflammation, oxidative stress, apoptosis, and liver fibrosis. Four-hundred and eighty participants were selected from the Miami Adult Studies on HIV (MASH) cohort, two-hundred and eleven were PLWH, and two-hundred and sixty-nine were uninfected controls. Biomarkers were analyzed from blood samples collected at the FIU Borinquen Clinic. Primary research outcomes were analyzed using multiple linear and logistic regression, pairwise analyses, and ROC curves. The TyG Index was determined to be a good predictor of liver steatosis among PLWH and uninfected controls (AUC=0.738 and AUC=0.702), respectively. Participants in the High TyG Risk category were 4.638 times more likely to have liver steatosis than those in the Low TyG Risk category [95% CI:(2.075, 10.368)]. Greater TyG Index was associated with higher immune activation markers Ln sCD14 (β=0.080, P=0.050) and Ln sCD163 (β=0.164, P=0.008). Linear regression analysis found HIV infection to be associated with higher levels sCD27 (β=0.181, P=0.005), and liver fibrosis pathway biomarkers LnTGF- β (β=0.915, P These data indicate a consistent relationship between increased TyG Index and biological pathways that lead to liver fibrosis. As liver disease becomes a more prominent concern among PLWH, it is crucial for health care professionals to address markers of metabolic health, such as the TyG Index, as a means to effectively manage liver steatosis and avoid the development of liver fibrosis

Educating Lawyers: Preparation for the Profession of Law

Examines the unique aspects and limitations of legal education, as part of a series of reports from the foundation's Preparation for the Professions Program

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel.

Pexidartinib (PLX3397) is a small molecule tyrosine kinase and colony-stimulating factor-1 inhibitor with FDA breakthrough therapy designation for tenosynovial giant-cell tumor, and currently under study in several other tumor types, including breast cancer, non-Hodgkin's lymphoma, and glioblastoma. Here, we report a case of severe drug-induced liver injury requiring liver transplantation due to vanishing bile duct syndrome (VBDS) after exposure to pexidartinib in the I-SPY 2 Trial, a phase 2 multicenter randomized neoadjuvant chemotherapy trial in patients with Stage II-III breast cancer. We also review the current literature on this rare, idiosyncratic, and potentially life-threatening entity